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Faster Dementia decline linked to incontinence medication
Among nursing home residents the 2 most common medical conditions are dementia and urinary incontinence; often they coexist. The problem is that the drugs used to treat each condition are pharmacological opposites, which can reduce the effectiveness of one or both drugs.
Kaycee M. Sink, MD, MAS, Wake Forest University School of Medicine, and colleagues, studied [...]
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0 Comment » Alzheimer’s treatment may be counter indicated for other forms of dementia
Dementia is an umbrella term used to describe various cognitive degenerative diseases. A common form of dementia is Alzheimer’s disease. A relatively rare hereditary form of dementia is frontotemporal dementia (FTD) with parkinsonism-17. Both of these forms of dementia share a common pathology–an over accumulation of tau proteins, which form tangled lesions in the brain’s neurons [...]
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Lou Gehrig’s disease research aided by yeast cells
During autopsies of brains, of people who had lateral sclerosis (ALS, aka Lou Gehrig’s disease) or frontotemporal dementia (FTD), a protein called TDP-43 was observed to accumulate abnormally. Further studies confirmed the damaging role of TDP-43.
Aaron D. Gitler, PhD, Assistant Professor of Cell and Developmental Biology, University of Pennsylvania School of Medicine, sought a way to screen [...]
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Dementia linked to hypertension and diabetes
Dr. Thomas Montine, University of Washington, autopsied the brains of 3,400 men and women who had experienced cognitive decline and dementia.
45% of the risk for dementia was associated with pathologic changes of Alzheimer’s disease.
10% of dementia risk was associated with Lewy bodies (neocortical structural changes that indicate a degenerative brain disease known as Lewy Body [...]
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Alzheimer’s a greater risk for women
As baby-boomers age their risks of developing dementia, Alzheimer’s disease, or heart disease increases. Stroke and dementia are the most widely feared age-related neurological diseases, and are also the only neurological disorders listed in the 10 leading causes of disease burden.
Researchers from Boston University School of Medicine (BUSM) followed 2,794 participants of the Framingham Heart [...]
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Alzheimer’s brains found to have high levels of iron
A recent study found that Alzheimer’s patients have an elevated level of magnetic iron oxides in the area of the brain that is affected by the disease.
Jon Dobson, professor, Keele University, Staffordshire, UK, looked at the brain tissue from 11 Alzheimer’s disease patients and 11 age-matched control subjects. For the first time it shows that [...]
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Alzheimer’s more likely when both parents have the disease
The leading cause of cognitive impairment in the U.S. elderly is Alzheimer’s disease. Because it is so common it is not unusual for both parents to develop the disease and presumably their offspring would be more likely to carry any genes associated with Alzheimer’s disease.
Suman Jayadev, MD, University of Washington, Seattle, and co-researchers, studied 111 families [...]
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Alzheimer’s detection improved along with other forms of dementia
Today positron emission tomography (PET) imaging is commonly used to differentiate various forms of dementia. The limitation of PET scans is that it only looks at the surface of the brain, which reduces the accuracy in determining the type of dementia the patient has developed.
Lisa Mosconi, PhD, assistant professor of psychiatry, New York University School of [...]
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Are Alzheimer’s patients better off knowing their diagnosis?
Physicians often have to grapple with the question if their patients are better off knowing their diagnosis of a life-changing disease or should the information be kept from them so what time they have left will be lived as fully as possible. A 2004 review of research found about half of all physicians were reluctant [...]
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Advanced dementia patients and antibiotic use
At the end of the lives of the more than 5 million Americans with dementia approximately 70% of them will live in nursing homes. Common among these patients are recurrent infections and fever.
Erika D’Agata, M.D., M.P.H., Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, studied 214 residents in 21 nursing homes with advanced dementia. [...]
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