Recently there have been reports that non-steroidal anti-inflammatory drugs (NSAIDs) have shown a lower risk of Alzheimer’s disease. Principally, the NSAID drugs naproxen and celecoxib have been cited as improving cognitive function in older adults with a family history of Alzheimer’s disease.
The Alzheimer’s Disease Anti-Inflammatory Prevention Trial (ADAPT) Research Group studied 2,117 individuals, 70 years and older, who have a family history of Alzheimer’s. For 3 years the participants were tested annually for cognitive function.
Six months after the study was terminated (because another study found celecoxib increased cardiovascular risks) the use of NSAIDs did not show a protective effect and in fact naproxen users had a lower cognitive assessment score when compared to celecoxib and the placebo.
Why the difference? Several explanations were offered:
Researchers conclude that naproxen and celecoxib should not be used for the prevention of Alzheimer’s disease.